The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value...

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Detalhes bibliográficos
Autor principal: Xavier-Magalhães, Ana (author)
Outros Autores: Gonçalves, Céline S (author), Fogli, Anne (author), Lourenço, Tatiana (author), Pojo, Marta (author), Pereira, Bruno (author), Rocha, Miguel (author), Celeste Lopes, Maria (author), Crespo, Inês (author), Rebelo, Olinda (author), Tão, Herminio (author), Lima, João (author), Moreira, Ricardo (author), Pinto, Afonso A (author), Jones, Chris (author), Reis, Rui M. (author), Costello, Joseph F (author), Arnaud, Philippe (author), Sousa, Nuno (author), Costa, Bruno Marques (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
HOTAIR
glioblastoma
glioma
prognosis
HOXA9
Texto completo:http://hdl.handle.net/1822/61532
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61532

Texto Completo

http://hdl.handle.net/1822/61532

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