Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatm...

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Bibliographic Details
Main Author: Pereira, Gonçalo C. (author)
Other Authors: Pereira, Susana P. (author), Tavares, Ludgero C. (author), Carvalho, Filipa S. (author), Magalhães-Novais, Sílvia (author), Barbosa, Inês A. (author), Santos, Maria S. (author), Bjork, James (author), Moreno, António J. (author), Wallace, Kendall B. (author), Oliveira, Paulo J. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Animals
Antibiotics, Antineoplastic
Cardiolipins
Cytochromes c
Doxorubicin
Kidney
Liver
Male
Mitochondria
Mitochondrial Myopathies
Myocardium
Rats, Wistar
Online Access:http://hdl.handle.net/10316/47559
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/47559

Internet

http://hdl.handle.net/10316/47559

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