BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular admi...

Full description

Bibliographic Details
Main Author: Lopes, C (author)
Other Authors: Gonçalves, N (author), Gomes, C (author), Saraiva, MJ (author), Pêgo, AP (author)
Format: article
Language:eng
Published: 2017
Subjects:
Brain-derived neurotrophic factor
Gene therapy
Neuron-targeted nanoparticles
Neuropathies
Neuroprotection
Trimethyl chitosan
Online Access:https://hdl.handle.net/10216/120724
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120724

Internet

https://hdl.handle.net/10216/120724

Similar Items