Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis

4-Hydroxytamoxifen (OHTAM) is the most active metabolite of the widely prescribed anticancer drug tamoxifen (TAM) used in breast cancer therapy. This work describes the effects of OHTAM on isolated human erythrocytes, using standardized test conditions, to check for a putative contribution to the TA...

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Detalhes bibliográficos
Autor principal: Cruz Silva, M. M. (author)
Outros Autores: Madeira, V. M. C. (author), Almeida, L. M. (author), Custódio, J. B. A. (author)
Formato: article
Idioma:eng
Publicado em: 2001
Assuntos:
4-Hydroxytamoxifen
Tamoxifen
Human erythrocytes
Hemolysis
Oxidative stress
Osmotic swelling
Texto completo:http://hdl.handle.net/10316/5795
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5795

Texto Completo

http://hdl.handle.net/10316/5795

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