Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis

4-Hydroxytamoxifen (OHTAM) is the most active metabolite of the widely prescribed anticancer drug tamoxifen (TAM) used in breast cancer therapy. This work describes the effects of OHTAM on isolated human erythrocytes, using standardized test conditions, to check for a putative contribution to the TA...

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Bibliographic Details
Main Author: Cruz Silva, M. M. (author)
Other Authors: Madeira, V. M. C. (author), Almeida, L. M. (author), Custódio, J. B. A. (author)
Format: article
Language:eng
Published: 2001
Subjects:
4-Hydroxytamoxifen
Tamoxifen
Human erythrocytes
Hemolysis
Oxidative stress
Osmotic swelling
Online Access:http://hdl.handle.net/10316/5795
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5795

Internet

http://hdl.handle.net/10316/5795

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