How mRNA translation can modulate nonsense-mediated decay

About one third of the gene mutations found in human genetic disorders, including cancer, result in premature translation-termination codons (PTCs) and the rapid degradation of the corresponding mRNAs by nonsense-mediated decay (NMD). However, we have found that human mRNAs with a PTC in close proxi...

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Detalhes bibliográficos
Autor principal: Romão, Luísa (author)
Formato: lecture
Idioma:eng
Publicado em: 2017
Assuntos:
Gene Mutations
Nonsense-mediated Decay (NMD)
Expressão Génica
Genómica Funcional e Estrutural
Texto completo:http://hdl.handle.net/10400.18/5423
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5423

Texto Completo

http://hdl.handle.net/10400.18/5423

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