Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation

Li+ is the most effective drug used to treat bipolar disorder; however, its exact mechanism of action has yet to be elucidated. One hypothesis is that Li+ competes with Mg2+ for the Mg2+ binding sites on guanine-nucleotide binding proteins (G-proteins). Using 7Li T1 relaxation measurements and fluor...

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Bibliographic Details
Main Author: Srinivasan, Chandra (author)
Other Authors: Toon, Jason (author), Amari, Louis (author), Abukhdeir, Abde M. (author), Hamm, Heidi (author), Geraldes, Carlos F. G. C. (author), Ho, Yee-Kin (author), Freitas, Duarte Mota de (author)
Format: article
Language:eng
Published: 2004
Subjects:
Transducin
G-proteins
Lithium
Magnesium
Ionic competition
Online Access:http://hdl.handle.net/10316/3868
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/3868

Internet

http://hdl.handle.net/10316/3868

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