Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A(2B) receptor antagonists

A new series of 9-deazaxanthine derivatives with various substituents at the heterocyclic system were synthesized and evaluated for their binding affinities for the four human recombinant adenosine receptors, A(1)-A(3) subtypes. A number of the 9-deazaxanthines derivatives 3a-m showed moderate-to-hi...

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Detalhes bibliográficos
Autor principal: Isabel Nieto, MI (author)
Outros Autores: Carmen Balo, MC (author), Brea, J (author), Caamano, O (author), Fernandez, F (author), Garcia Mera, X (author), Lopez, C (author), Isabel Loza, MI (author), Rodriguez Borges, JE (author), Vidal, B (author)
Formato: article
Idioma:eng
Publicado em: 2010
Assuntos:
Química clínica, Neuroquímica, Química orgânica, Engenharia química
Clinical chemistry, Neurochemistry, Organic chemistry, Chemical engineering
Texto completo:https://hdl.handle.net/10216/98112
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/98112

Texto Completo

https://hdl.handle.net/10216/98112

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