Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics

Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune res

Detalhes bibliográficos
Autor principal: Lemey, Philippe (author)
Outros Autores: Kosakovsky Pond, Sergei L. (author), Drummond, Alexei J. (author), Pybus, Oliver G. (author), Shapiro, Beth (author), Barroso, Helena (author), Taveira, Nuno (author), Rambaut, Andrew (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemical Research Methods
Mathematical & Computational Biology
Texto completo:http://hdl.handle.net/10451/21395
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21395
Descrição
Resumo:Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune res

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