4-Hydroxytamoxifen is a potent inhibitor of the mitochondrial permeability transition

The effects of 4-hydroxytamoxifen (OHTAM), the major active metabolite of the antiestrogen tamoxifen used in the breast cancer therapy, were studied on the mitochondrial permeability transition (MPT) and bioenergetic functions of mitochondria to evaluate the mechanisms underlying the cell death and...

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Bibliographic Details
Main Author: Cardoso, Carla M. P. (author)
Other Authors: Almeida, Leonor M. (author), Custódio, José B. A. (author)
Format: article
Language:eng
Published: 2002
Subjects:
4-Hydroxytamoxifen
Anticancer drug
Breast cancer
Mitochondrial bioenergetics
Mitochondrial permeability transition
Oxidative stress
Online Access:http://hdl.handle.net/10316/5789
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5789

Internet

http://hdl.handle.net/10316/5789

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