Differential mtDNA damage patterns in a transgenic mouse model of Machado-Joseph disease (MJD/SCA3)

Mitochondrial dysfunction has been associated with late onset neurodegenerative disorders, among which is Machado-Joseph disease (MJD/SCA3). In a previous study, using a transgenic mouse model of MJD, we reported a decrease in mitochondrial DNA (mtDNA) copy number and an accumulation of the 3876-bp...

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Bibliographic Details
Main Author: Ramos, Amanda (author)
Other Authors: Kazachkova, Nadiya (author), Silva, Francisca (author), Maciel, P. (author), Fernandes, Anabela Silva (author), Silva, Sara Carina Duarte (author), Santos, Cristina (author), Lima, Manuela (author)
Format: article
Language:eng
Published: 2015
Subjects:
Mitochondrial DNA
mtDNA damage
Machado-Joseph disease
Transgenic mouse model
Neurodegenerative disorder
Polyglutamine disorder
Science & Technology
Online Access:http://hdl.handle.net/1822/32524
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/32524

Internet

http://hdl.handle.net/1822/32524

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