The actin-binding protein α-adducin is required for maintaining axon diameter

The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. a-adducin knockout mice presented progressive axon enlargement in the spinal cord and opti...

Full description

Bibliographic Details
Main Author: Leite, SC (author)
Other Authors: Sampaio, P (author), Sousa, VF (author), Nogueira-Rodrigues, J (author), Pinto-Costa, R (author), Peters, LL (author), Brites, P (author), Sousa, MM (author)
Format: article
Language:eng
Published: 2016
Subjects:
Animals
Axonal Transport
Axons/metabolism
Calmodulin-Binding Proteins/metabolism
Cytoskeleton/metabolism
Growth Cones/metabolism
Hippocampus/pathology
Mice Inbred C57BL
Mice Knockout
Microfilament Proteins/metabolism
Nerve Degeneration/metabolism
Nerve Degeneration/pathology
Online Access:http://hdl.handle.net/10216/110361
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110361

Internet

http://hdl.handle.net/10216/110361

Similar Items