The actin-binding protein α-adducin is required for maintaining axon diameter

The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. a-adducin knockout mice presented progressive axon enlargement in the spinal cord and opti...

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Detalhes bibliográficos
Autor principal: Leite, SC (author)
Outros Autores: Sampaio, P (author), Sousa, VF (author), Nogueira-Rodrigues, J (author), Pinto-Costa, R (author), Peters, LL (author), Brites, P (author), Sousa, MM (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Animals
Axonal Transport
Axons/metabolism
Calmodulin-Binding Proteins/metabolism
Cytoskeleton/metabolism
Growth Cones/metabolism
Hippocampus/pathology
Mice Inbred C57BL
Mice Knockout
Microfilament Proteins/metabolism
Nerve Degeneration/metabolism
Nerve Degeneration/pathology
Texto completo:http://hdl.handle.net/10216/110361
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110361

Texto Completo

http://hdl.handle.net/10216/110361

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