New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is a tyrosine kinase receptor, expressed primarily in endothelial cells, and is activated by the specific binding of VEGF, produced and released by the tumor, to the VEGFR2 extracellular regulatory domain, undergoing autophosphorylation, trigger...

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Detalhes bibliográficos
Autor principal: Machado, Vera A. (author)
Outros Autores: Costa, Raquel (author), Peixoto, Daniela (author), Abreu, Rui M.V. (author), Calhelha, Ricardo C. (author), Ferreira, Isabel C.F.R. (author), Soares, Raquel (author), Queiroz, Maria João R.P. (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2015
Texto completo:http://hdl.handle.net/10198/12279
País:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/12279

Texto Completo

http://hdl.handle.net/10198/12279

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