New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is a tyrosine kinase receptor, expressed primarily in endothelial cells, and is activated by the specific binding of VEGF, produced and released by the tumor, to the VEGFR2 extracellular regulatory domain, undergoing autophosphorylation, trigger...

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Bibliographic Details
Main Author: Machado, Vera A. (author)
Other Authors: Costa, Raquel (author), Peixoto, Daniela (author), Abreu, Rui M.V. (author), Calhelha, Ricardo C. (author), Ferreira, Isabel C.F.R. (author), Soares, Raquel (author), Queiroz, Maria João R.P. (author)
Format: conferenceObject
Language:eng
Published: 2015
Online Access:http://hdl.handle.net/10198/12279
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/12279

Internet

http://hdl.handle.net/10198/12279

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