Initial screening of poly(ethylene glycol) amino ligands for affinity purification of plasmid DNA in aqueous two-phase systems

Gene therapy and DNA vaccination are among the most expected biotechnological and medical advances for the coming years. However, the lack of cost-effective large-scale production and purification of pharmaceutical-grade plasmid DNA (pDNA) still hampers their wide application. Downstream processing,...

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Bibliographic Details
Main Author: Silva, Nuno Miguel Sampaio Ribeiro Magalhães (author)
Other Authors: Jorge, Paula Alexandra Silva (author), Martins, José A. (author), Teixeira, J. A. (author), Marcos, João C. (author)
Format: article
Language:eng
Published: 2021
Subjects:
Aqueous two-phase systems
Affinity partition
Non-viral vectors
Plasmid DNA purification
Gene therapy
DNA vaccines
Science & Technology
Online Access:https://hdl.handle.net/1822/74590
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/74590

Internet

https://hdl.handle.net/1822/74590

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