Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies
Insoluble and fibrillar forms of a-synuclein are the major components of Lewy bodies, a hallmark of several sporadic and inherited neurodegenerative diseases known as synucleinopathies. a-Synuclein is a natural unfolded and aggregation-prone protein that can be degraded by the ubiquitin-proteasomal...
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| Format: | article |
| Language: | eng |
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2015
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| Online Access: | http://hdl.handle.net/1822/40088 |
| Country: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/40088 |