Synthesis and bioactivity of new analogue of Bicyclic 1-Azafagomine
New (S)-(1,2,3,6-tetrahydropyridazin-3-yl)methanol was synthesized by Lewis acid catalyzed and self-assembled Diels-Alder (LACASA-DA) cycloaddition reaction using (S)-BINOL as a chiral inductor. The N-2 pyridazine position was protected, the hydroxyl group was carbonylated to form the new bicyclic s...
Main Author: | |
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Other Authors: | , , , |
Format: | article |
Language: | eng |
Published: |
2019
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Subjects: | |
Online Access: | http://hdl.handle.net/1822/73402 |
Country: | Portugal |
Oai: | oai:repositorium.sdum.uminho.pt:1822/73402 |