Towards a structural understanding of the fibrillization pathway in Machado-Joseph’s disease: trapping early oligomers of non-expanded ataxin-3

Machado-Joseph’s disease is caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein ataxin-3. Except for the polyglutamine region, proteins associated with polyglutamine diseases are unrelated, and for all of these diseases aggrega...

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Bibliographic Details
Main Author: Gales, Luís (author)
Other Authors: Cortes, Luísa (author), Almeida, Carla (author), Melo, Carlos V. (author), Costa, Maria do Carmo (author), Maciel, P. (author), Clarke, David T. (author), Damas, Ana Margarida (author), Ribeiro, Sandra Macedo (author)
Format: article
Language:eng
Published: 2005
Subjects:
SCA3
Self-assembly domain
Neurodegenerative
Polyglutamine
Amyloid
Science & Technology
Online Access:http://hdl.handle.net/1822/5743
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/5743

Internet

http://hdl.handle.net/1822/5743

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