Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1

We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the...

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Bibliographic Details
Main Author: Brito, Alexandra (author)
Other Authors: Pereira, Patrícia M. (author), Costa, Diana Soares da (author), Reis, R. L. (author), Ulijn, Rein V. (author), Lewis, Rein V. (author), Pires, R. A. (author), Pashkuleva, I. (author)
Format: article
Language:eng
Published: 2020
Subjects:
Apoptosis
Biocatalytic self-assembly
GLUT inhibitor
Osteosarcoma
Warburg effect
Science & Technology
Online Access:http://hdl.handle.net/1822/66345
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/66345

Internet

http://hdl.handle.net/1822/66345

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