Tamoxifen Inhibits Induction of the Mitochondrial Permeability Transition by Ca2+and Inorganic Phosphate

Tamoxifen (TAM) is a synthetic, nonsteroidal antiestrogenic agent that is widely prescribed in the treatment of estrogen-dependent neoplasias, including breast cancer. The mechanism of action has yet to be defined, but likely is independent of estrogen receptor binding. In light of its high lipophil...

Full description

Bibliographic Details
Main Author: Custódio, José B. A. (author)
Other Authors: Moreno, António J. M. (author), Wallace, Kendall B. (author)
Format: article
Language:eng
Published: 1998
Subjects:
Online Access:http://hdl.handle.net/10316/5825
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5825