Discovery of a New Inhibitor of P53/MDM2 Interaction Using a Yeast Target-based Screening Strategy
The p53 tumour suppressor is a major regulator of cell proliferation and death.In tumours that retain a wild-type (wt) p53, the activity of this protein can beinhibited by the endogenous negative regulator MDM2. In this case, inhibitorsof p53/MDM2 interaction have been considered promising drugs for...
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| Formato: | conferenceObject |
| Idioma: | eng |
| Publicado em: |
2012
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| Texto completo: | https://repositorio-aberto.up.pt/handle/10216/80656 |
| País: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/80656 |