Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis

Deregulation of proteostasis is a main feature of many age-related diseases, often leading to the accumulation of toxic oligomers and insoluble protein aggregates that accumulate intracellularly or in the extracellular space. To understand the mechanisms whereby toxic or otherwise unwanted proteins...

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Detalhes bibliográficos
Autor principal: Ferreira, Joao Vasco (author)
Outros Autores: Soares, Ana Rosa (author), Ramalho, José S. (author), Ribeiro-Rodrigues, Teresa (author), Máximo, Catarina (author), Zuzarte, Mónica (author), Girão, Henrique (author), Pereira, Paulo (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Texto completo:https://doi.org/10.1371/journal.pone.0223790
País:Portugal
Oai:oai:run.unl.pt:10362/85727