DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Detalhes bibliográficos
Autor principal: Howarth, Alison (author)
Outros Autores: Simms, Claire (author), Kerai, Nitesh (author), Allen, Olivia (author), Mihajluk, Karina (author), Madureira, Patricia (author), Sokratous, Giannis (author), Cragg, Simon (author), Lee, Sang Y. (author), Morley, Andy D. (author), Ashkan, Keyoumars (author), Cox, Paul A. (author), Pilkington, Geoffrey J. (author), Hill, Richard (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Brain-stem glioma
Vincristine chemotherapy
Texto completo:http://hdl.handle.net/10400.1/13459
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13459

Texto Completo

http://hdl.handle.net/10400.1/13459

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