Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl-CoA availability and increases plant polyphenol synthesis

In recent years microorganisms have been engineered towards synthesizing interesting plant polyphenols such as flavonoids and stilbenes from glucose. Currently, low endogenous supply of malonylCoA, indispensable for plant polyphenol synthesis, impedes high product titers. Usually, limited malonylCoA...

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Bibliographic Details
Main Author: Milke, Lars (author)
Other Authors: Ferreira, Patrícia (author), Kallscheuer, Nicolai (author), Braga, Adelaide (author), Vogt, Michael (author), Kappelmann, Jannick (author), Oliveira, Joana (author), Silva, Ana Rita (author), Rocha, I. (author), Bott, Michael (author), Noack, Stephan (author), Faria, N. (author), Marienhagen, Jan (author)
Format: article
Language:eng
Published: 2019
Subjects:
citrate synthase
Corynebacterium glutamicum
malonyl-CoA
naringenin
polyphenols
resveratrol
Science & Technology
Online Access:http://hdl.handle.net/1822/60355
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/60355

Internet

http://hdl.handle.net/1822/60355

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