Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl-CoA availability and increases plant polyphenol synthesis

In recent years microorganisms have been engineered towards synthesizing interesting plant polyphenols such as flavonoids and stilbenes from glucose. Currently, low endogenous supply of malonylCoA, indispensable for plant polyphenol synthesis, impedes high product titers. Usually, limited malonylCoA...

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Detalhes bibliográficos
Autor principal: Milke, Lars (author)
Outros Autores: Ferreira, Patrícia (author), Kallscheuer, Nicolai (author), Braga, Adelaide (author), Vogt, Michael (author), Kappelmann, Jannick (author), Oliveira, Joana (author), Silva, Ana Rita (author), Rocha, I. (author), Bott, Michael (author), Noack, Stephan (author), Faria, N. (author), Marienhagen, Jan (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
citrate synthase
Corynebacterium glutamicum
malonyl-CoA
naringenin
polyphenols
resveratrol
Science & Technology
Texto completo:http://hdl.handle.net/1822/60355
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/60355

Texto Completo

http://hdl.handle.net/1822/60355

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