A two-step mechanism for epigenetic specification of centromere identity and function

The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is demonstrated to be the epigenetic mark that acts th...

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Bibliographic Details
Main Author: Fachinetti, Daniele (author)
Other Authors: Diego Folco, H. (author), Nechemia-Arbely, Yael (author), Valente, Luis P. (author), Nguyen, Kristen (author), Wong, Alex J. (author), Zhu, Quan (author), Holland, Andrew J. (author), Desai, Arshad (author), Jansen, Lars E. T. (author), Cleveland, Don W. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adenoviridae
Autoantigens
Centromere
Centromere Protein B
Chromatin
Chromosomal Proteins, Non-Histone
Epithelial Cells
Genetic Vectors
Histones
Humans
Protein Structure, Tertiary
Retina
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Signal Transduction
Epigenesis, Genetic
Online Access:http://hdl.handle.net/10400.7/625
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/625

Internet

http://hdl.handle.net/10400.7/625

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