A two-step mechanism for epigenetic specification of centromere identity and function

The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is demonstrated to be the epigenetic mark that acts th...

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Detalhes bibliográficos
Autor principal: Fachinetti, Daniele (author)
Outros Autores: Diego Folco, H. (author), Nechemia-Arbely, Yael (author), Valente, Luis P. (author), Nguyen, Kristen (author), Wong, Alex J. (author), Zhu, Quan (author), Holland, Andrew J. (author), Desai, Arshad (author), Jansen, Lars E. T. (author), Cleveland, Don W. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Adenoviridae
Autoantigens
Centromere
Centromere Protein B
Chromatin
Chromosomal Proteins, Non-Histone
Epithelial Cells
Genetic Vectors
Histones
Humans
Protein Structure, Tertiary
Retina
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Signal Transduction
Epigenesis, Genetic
Texto completo:http://hdl.handle.net/10400.7/625
País:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/625

Texto Completo

http://hdl.handle.net/10400.7/625

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