Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Fox...

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Detalhes bibliográficos
Autor principal: Costa, Nuno (author)
Outros Autores: Pires, Ana E. (author), Gabriel, Ana M. (author), Goulart, Luiz F. (author), Pereira, Clara (author), Leal, Bárbara (author), Queiros, Ana C. (author), Chaara, Wahiba (author), Moraes-Fontes, Maria F. (author), Vasconcelos, Carlos (author), Ferreira, Carlos (author), Martins, Jorge (author), Bastos, Marina (author), Santos, Maria J. (author), Pereira, Maria A. (author), Martins, Berta (author), Lima, Margarida (author), João, Cristina (author), Six, Adrien (author), Demengeot, Jocelyne (author), Fesel, Constantin (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Adult
Forkhead Transcription Factors
Humans
Interleukin-2 Receptor alpha Subunit
Longitudinal Studies
Lupus Erythematosus, Systemic
Middle Aged
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets
T-Lymphocytes, Regulatory
Young Adult
Immunoglobulins, Intravenous
Texto completo:http://hdl.handle.net/10400.7/676
País:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/676

Texto Completo

http://hdl.handle.net/10400.7/676

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