Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Fox...

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Bibliographic Details
Main Author: Costa, Nuno (author)
Other Authors: Pires, Ana E. (author), Gabriel, Ana M. (author), Goulart, Luiz F. (author), Pereira, Clara (author), Leal, Bárbara (author), Queiros, Ana C. (author), Chaara, Wahiba (author), Moraes-Fontes, Maria F. (author), Vasconcelos, Carlos (author), Ferreira, Carlos (author), Martins, Jorge (author), Bastos, Marina (author), Santos, Maria J. (author), Pereira, Maria A. (author), Martins, Berta (author), Lima, Margarida (author), João, Cristina (author), Six, Adrien (author), Demengeot, Jocelyne (author), Fesel, Constantin (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adult
Forkhead Transcription Factors
Humans
Interleukin-2 Receptor alpha Subunit
Longitudinal Studies
Lupus Erythematosus, Systemic
Middle Aged
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets
T-Lymphocytes, Regulatory
Young Adult
Immunoglobulins, Intravenous
Online Access:http://hdl.handle.net/10400.7/676
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/676

Internet

http://hdl.handle.net/10400.7/676

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