Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors

Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in angiogenesis. Herein, we report the synthesis of novel1-aryl-3-[2-, 3- or 4-{thieno[3,2-b ]pyridin-7-ylthio) phenyl]ureas as VEGFR2 inhibitors by promoting the regioselective attack of the thiol group...

Full description

Bibliographic Details
Main Author: Peixoto, Daniela (author)
Other Authors: Queiroz, Maria João R.P. (author), Abreu, Rui M.V. (author), Froufe, Hugo J.C. (author), Calhelha, Ricardo C. (author), Ferreira, Isabel C.F.R. (author)
Format: conferenceObject
Language:eng
Published: 2013
Online Access:http://hdl.handle.net/10198/7835
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/7835

Internet

http://hdl.handle.net/10198/7835

Similar Items