Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy
Alpha-synuclein (syn) is the main component of proteinaceous inclusions known as Lewy bodies (LB5), which are implicated in the pathogenesis of the neurodegenerative diseases known as synucleinopathies, like Parkinson's disease (PD). Aging is a major risk factor for PD and thus, interventions t...
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| Outros Autores: | , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2017
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| Texto completo: | http://hdl.handle.net/1822/48395 |
| País: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/48395 |