Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy

Alpha-synuclein (syn) is the main component of proteinaceous inclusions known as Lewy bodies (LB5), which are implicated in the pathogenesis of the neurodegenerative diseases known as synucleinopathies, like Parkinson's disease (PD). Aging is a major risk factor for PD and thus, interventions t...

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Bibliographic Details
Main Author: Guedes, Ana (author)
Other Authors: Ludovico, Paula (author), Marques, Maria Belém Sousa Sampaio (author)
Format: article
Language:eng
Published: 2017
Subjects:
Caloric restriction
Autophagy
Sirtuins
Alpha-synuclein
Synucleinopathies
Science & Technology
Online Access:http://hdl.handle.net/1822/48395
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/48395

Internet

http://hdl.handle.net/1822/48395

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