Testing the combinatory use of PARP1 and RPA inhibitors in breast cancer cell lines
Loss of tumor suppressor BRCA2 is strongly associated to breast cancer. BRCA2 is essential to homologous recombination (HR), which is a DNA repair pathway crucial to genomic stability. When cells become mutant for BRCA2, they cannot repair DNA damage through homologous recombination, which is an acc...
| Main Author: | |
|---|---|
| Format: | masterThesis |
| Language: | eng |
| Published: |
2019
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10773/29527 |
| Country: | Portugal |
| Oai: | oai:ria.ua.pt:10773/29527 |