Phosphorylated silk fibroin matrix for methotrexate release

Silk-based matrix was produced for delivery of a model anticancer drug, methotrexate (MTX). The calculation of net charge of silk fibroin and MTX was performed to better understand the electrostatic interactions during matrix formation upon casting. Silk fibroin films were cast at pH 7.2 and pH 3.5....

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Bibliographic Details
Main Author: Volkov, Vadim (author)
Other Authors: Sárria, M. P. (author), Gomes, A. C. (author), Paulo, Artur Cavaco (author)
Format: article
Language:eng
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/1822/32905
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/32905