Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species

AIMS: In this work, we studied the mechanisms by which diphenyleneiodonium chloride (DPI) inhibits nitric oxide (NO) synthesis induced by the proinflammatory cytokine interleukin-1beta (IL-1) in bovine articular chondrocytes. To achieve this, we evaluated the ability of DPI to inhibit the expression...

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Bibliographic Details
Main Author: Mendes, A. Ferreira (author)
Other Authors: Carvalho, A. Pato (author), Caramona, M. Margarida (author), Lopes, M. Celeste (author)
Format: article
Language:eng
Published: 2001
Subjects:
Reactive oxygen species
Flavonoid-containing enzymes
Diphenyleneiodonium chloride
Pro-inflammatory cytokines
Chondrocyte
Arthritis
Online Access:http://hdl.handle.net/10316/12766
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/12766

Internet

http://hdl.handle.net/10316/12766

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