Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...

Full description

Bibliographic Details
Main Author: Cavadas, Miguel (author)
Other Authors: Oikonomidi, Ioanna (author), Gaspar, Catarina J. (author), Burbridge, Emma (author), Badenes, Marina (author), Félix, Inês (author), Bolado, Alfonso (author), Hu, Tianyi (author), Bileck, Andrea (author), Gerner, Christopher (author), Domingos, Pedro M. (author), von Kriegsheim, Alex (author), Adrain, Colin (author)
Format: article
Language:eng
Published: 2020
Subjects:
14-3-3
ADAM metalloproteases
ADAM17/TACE
ectodomain shedding
EGFR
iRhom2
MAP kinases
TNF
Biochemistry, Genetics and Molecular Biology(all)
Online Access:http://hdl.handle.net/10362/92266
Country:Portugal
Oai:oai:run.unl.pt:10362/92266

Internet

http://hdl.handle.net/10362/92266

Similar Items