Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...

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Detalhes bibliográficos
Autor principal: Cavadas, Miguel (author)
Outros Autores: Oikonomidi, Ioanna (author), Gaspar, Catarina J. (author), Burbridge, Emma (author), Badenes, Marina (author), Félix, Inês (author), Bolado, Alfonso (author), Hu, Tianyi (author), Bileck, Andrea (author), Gerner, Christopher (author), Domingos, Pedro M. (author), von Kriegsheim, Alex (author), Adrain, Colin (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
14-3-3
ADAM metalloproteases
ADAM17/TACE
ectodomain shedding
EGFR
iRhom2
MAP kinases
TNF
Biochemistry, Genetics and Molecular Biology(all)
Texto completo:http://hdl.handle.net/10362/92266
País:Portugal
Oai:oai:run.unl.pt:10362/92266

Texto Completo

http://hdl.handle.net/10362/92266

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