ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

BACKGROUND: Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger number o...

ver descrição completa

Detalhes bibliográficos
Autor principal: Rocha, S (author)
Outros Autores: Vieira, J (author), Vázquez, N (author), López-Fernández, H (author), Fdez-Riverola, F (author), Reboiro-Jato, M (author), Sousa, AD (author), Vieira, CP (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Binding interface
Expanded ATXN1
Protein-protein interaction
Wild-type ATXN1
Texto completo:https://hdl.handle.net/10216/123929
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/123929

Texto Completo

https://hdl.handle.net/10216/123929

Registros relacionados