ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

BACKGROUND: Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger number o...

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Bibliographic Details
Main Author: Rocha, S (author)
Other Authors: Vieira, J (author), Vázquez, N (author), López-Fernández, H (author), Fdez-Riverola, F (author), Reboiro-Jato, M (author), Sousa, AD (author), Vieira, CP (author)
Format: article
Language:eng
Published: 2019
Subjects:
Binding interface
Expanded ATXN1
Protein-protein interaction
Wild-type ATXN1
Online Access:https://hdl.handle.net/10216/123929
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/123929

Internet

https://hdl.handle.net/10216/123929

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