Machado-Joseph disease in a Nigerian family: mutational origin and review of the literature

Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16...

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Detalhes bibliográficos
Autor principal: Ogun, SA (author)
Outros Autores: Martins, S (author), Adebayo, PB (author), Dawodu, CO (author), Sequeiros, J (author), Finkel, MF (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Adult
African Continental Ancestry Group
Ataxin-3
Female
Haplotypes
Human Migration
Humans
Machado-Joseph Disease/diagnosis
Machado-Joseph Disease/epidemiology
Machado-Joseph Disease/ethnology
Machado-Joseph Disease/genetics
Male
Mutation
Nerve Tissue Proteins/genetics
Nigeria
Nuclear Proteins/genetics
Pedigree
Portugal
Repressor Proteins/genetics
Texto completo:http://hdl.handle.net/10216/114495
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114495

Texto Completo

http://hdl.handle.net/10216/114495

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