Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice

The prevalence of Alzheimer's disease (AD), the most common cause of age-associated dementia, is estimated to increase over the next decades. Evidence suggests neuro-immune signaling deregulation and risk genes beyond the amyloid-β (Aβ) deposition in AD pathology. We examined the temporal profi...

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Bibliographic Details
Main Author: Fernandes, Adelaide (author)
Other Authors: Caldeira, Cláudia (author), Cunha, Carolina (author), Ferreiro, Elisabete (author), Vaz, Ana Rita (author), Brites, Dora (author)
Format: article
Language:eng
Published: 2022
Subjects:
Alzheimer’s disease
APP processing
dysregulated gene-associated biomarkers
inflammatory-associated miRNAs
microglia reactivity
miR-155 targets
3xTg-AD mouse model
Alzheimer Disease
Animals
Disease Models, Animal
Disease Progression
Mice
Mice, Transgenic
Up-Regulation
Online Access:http://hdl.handle.net/10316/103216
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103216

Internet

http://hdl.handle.net/10316/103216

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