Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

Background Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNAs...

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Detalhes bibliográficos
Autor principal: Ramalho-Carvalho, João (author)
Outros Autores: Pinho dos Santos Graça, Maria Inês (author), Gomez, Antonio (author), Oliveira, Jorge (author), Henrique, Rui (author), Esteller, Manel (author), Jerónimo, Carmen (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
miR-130b
Cell Cycle
Cell Line, Tumor
Cellular Senescence
DNA Damage
DNA Repair
MicroRNAs
Prostatic Neoplasms
DNA Methylation
Texto completo:http://hdl.handle.net/10400.22/13747
País:Portugal
Oai:oai:recipp.ipp.pt:10400.22/13747

Texto Completo

http://hdl.handle.net/10400.22/13747

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