Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Detalhes bibliográficos
Autor principal: Miranda-Gonçalves, V. (author)
Outros Autores: Granja, S. (author), Martinho, O. (author), Honavar, M. (author), Pojo, M. (author), Costa, B. (author), Melo-Pires, M. (author), Pinheiro, C. (author), Cordeiro, M. (author), Bebiano, G. (author), Costa, P. (author), Reis, R. (author), Baltazar, F. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Warburg effect;
glioblastomas
lactate
monocarboxylate transporters (MCTs)
tumor hypoxia
Texto completo:http://hdl.handle.net/10400.16/2142
País:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2142

Texto Completo

http://hdl.handle.net/10400.16/2142

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