Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Bibliographic Details
Main Author: Miranda-Gonçalves, V. (author)
Other Authors: Granja, S. (author), Martinho, O. (author), Honavar, M. (author), Pojo, M. (author), Costa, B. (author), Melo-Pires, M. (author), Pinheiro, C. (author), Cordeiro, M. (author), Bebiano, G. (author), Costa, P. (author), Reis, R. (author), Baltazar, F. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Warburg effect;
glioblastomas
lactate
monocarboxylate transporters (MCTs)
tumor hypoxia
Online Access:http://hdl.handle.net/10400.16/2142
Country:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2142

Internet

http://hdl.handle.net/10400.16/2142

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