Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

Proteolytic cleavage of the Na(+)/Ca(2+) exchanger (NCX) by calpains impairs calcium homeostasis, leading to a delayed calcium overload and excitotoxic cell death. However, it is not known whether reversal of the exchanger contributes to activate calpains and trigger neuronal death. We investigated...

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Detalhes bibliográficos
Autor principal: Araújo, I. M. (author)
Outros Autores: Carreira, B. P. (author), Pereira, T. (author), Santos, P. F. (author), Soulet, D. (author), Inácio, A. (author), Bahr, B. A. (author), Carvalho, A. P. (author), Carvalho, C. M. (author)
Formato: article
Idioma:eng
Publicado em: 2007
Assuntos:
Excitotoxicity
Calcium
Calpains
Proteolysis
Sodium–calcium exchanger
AMPA receptors
Texto completo:http://hdl.handle.net/10316/12658
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/12658

Texto Completo

http://hdl.handle.net/10316/12658

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