Serial progression of cortical and medullary thymic epithelial microenvironments.

Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal s...

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Bibliographic Details
Main Author: Alves, NL (author)
Other Authors: Takahama, Y (author), Ohigashi, I (author), Ribeiro, AR (author), Baik, S (author), Anderson, G (author), Jenkinson, WE (author)
Format: article
Language:eng
Published: 2014
Subjects:
Animals
Autoimmunity
Cell Communication/immunology
Cell Differentiation
Cell Lineage
Epithelial Cells/immunology
Humans
Immunotherapy/methods
Immunotherapy/trends
Lymphoid Progenitor Cells/immunology
Mice
Models, Immunological
T-Lymphocyte Subsets/immunology
T-Lymphocytes, Regulatory/immunology
Thymus Gland/immunology
Online Access:http://hdl.handle.net/10216/114507
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114507

Internet

http://hdl.handle.net/10216/114507

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