Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for traf...

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Bibliographic Details
Main Author: Granja, Sara Costa (author)
Other Authors: Marchiq, Ibtissam (author), Le Floch, Renaud (author), Moura, Conceição Souto (author), Baltazar, Fátima (author), Pouysségur, Jacques (author)
Format: article
Language:eng
Published: 2015
Subjects:
Lung cancer
CD147
BASIGIN
Monocarboxylate transporters
MCTs
Lactate
Glycolytic metabolism
Metformin
ZFNs
Science & Technology
Online Access:http://hdl.handle.net/1822/32456
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/32456

Internet

http://hdl.handle.net/1822/32456

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