Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for traf...

ver descrição completa

Detalhes bibliográficos
Autor principal: Granja, Sara Costa (author)
Outros Autores: Marchiq, Ibtissam (author), Le Floch, Renaud (author), Moura, Conceição Souto (author), Baltazar, Fátima (author), Pouysségur, Jacques (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Lung cancer
CD147
BASIGIN
Monocarboxylate transporters
MCTs
Lactate
Glycolytic metabolism
Metformin
ZFNs
Science & Technology
Texto completo:http://hdl.handle.net/1822/32456
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/32456

Texto Completo

http://hdl.handle.net/1822/32456

Registros relacionados