Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells

Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related protein 1 or dynamin 1-like (DNM1L); GCL, glut...

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Detalhes bibliográficos
Autor principal: Ribeiro, Márcio (author)
Outros Autores: Rosenstock, Tatiana R. (author), Oliveira, Ana M. (author), Oliveira, Catarina R. (author), Rego, A. Cristina (author)
Formato: article
Idioma:eng
Publicado em: 2014
Assuntos:
Huntington disease
Oxidative stress
Insulin/IGF-1 signaling
Nrf2
Mitochondria
Reactive oxygen species
Striatal cells
Akt
Texto completo:http://hdl.handle.net/10316/27852
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/27852

Texto Completo

http://hdl.handle.net/10316/27852

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